Adderall and Depakote.: I failed Vyvanse for my ADD, so the doc has me trying Adderall. Seems to work pretty good, except for the irritability. Since I failed Vyvanse for my ADD, so the doc has me trying Adderall. Adderall is the brand name of a prescription medication used to treat attention deficit hyperactivity disorder (ADHD) in children and adults. Adderall is a combination of two stimulant drugs. How to use Depakote. Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking divalproex sodium and each time you get a refill. Doctors give unbiased, trusted information on the benefits and side effects of Adderall to treat Bipolar Disorder (Manic Depression): Dr. Srur on bipolar disorder and adderall: There are a number of conditions that fall under the spectrum of bipolar disorder. Essentially, bipolar disorder encompasses periods of low energy, low mood and other impairments (depression) as well as periods of high. What other drugs will affect Depakote? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Answer There are no documented problems with ADDERALL and DEPAKOTE so far. HOWEVER, you should check with your doctor before you take the following. Hey there, I also have both conditions and I've been taking the Adderall for my ADHD over the years. I think it's important to speak with the doctor if you are experiencing symptoms that are disrupting your normal pattern of life (if they are becoming a problem). I'm only speaking from my own perspective, but I've been on Depakote, Zoloft, and Abilify for the last five years or so, and I am Bipolar I with rapidly cycling mania and very little depression.